Chapter 16 New Infectious Threats

Overview

In Chapter 15, we saw how a new disease, HIV/AIDS, quickly spread around the globe, but many other diseases have also seen major changes in patterns of infection worldwide. Some of these infectious diseases are caused by bacteria instead of viruses. Unlike viral diseases, bacterial diseases can generally be treated by antibiotics. For the last half of the twentieth century, people thought that antibiotics would make widespread bacterial disease a thing of the past. Over time, however, many species of bacteria have, become resistant to antibiotics.

              In this chapter, we will mainly focus on human diseases. Keep in mind, however, that all organisms can suffer from disease. Production of disease-resistant strains of plants has been a major goal of both traditional plant breeding and of genetic engineering of plants (see Chapter 17). Diseases of agriculturally and domestically important animal species have long been a focus of research in veterinary medicine. Diseases among wild animal and plant species are a research focus in ecology because of their importance to the health of wild populations and because of their interaction with human disease. 

Although a particular organism can be demonstrated to be the causative agent of a disease (Chapter 15), there are many other factors that contribute to the spread of the disease in populations. The development of treatments for specific diseases in individuals depends on knowledge of the pathogen. However, development of public health strategies to prevent the spread of disease depends just as much on knowledge of the routes of transmission of the pathogen. One disease, smallpox, has been eliminated entirely.  However, according to the Centers for Disease Control and Prevention (CDC), some 30 new infectious diseases, including AIDS, SARS, MERS, and COVID-19, have emerged in the past few decades as technology and lifestyles have changed. Other infectious diseases have been with us for millennia; they may cycle through long periods of quiescence, only to re-emerge as epidemics once more.

Chapter Outline

Selected Videos

Review Questions

THE PURPOSE of these review quizzes is to guide students in where their knowledge and understanding is strong, where it is weak, and where time should best be spent in studying.

CHAPTER 16:

  1. What is a pathogen?  What is virulence?  How does virulence tend to evolve over time?  What is the difference between prevalence and incidence?  (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.1.)
  2. Name at least four sexually transmitted diseases.  Which ones are most common?  What can be done to minimize the risks for acquiring these diseases?  What is the history of tuberculosis infection in various parts of the world, and how have these patterns changed in recent decades?  What are some other diseases that have recently spread by direct contact?  (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.2.)
  3. What is Creutzfeld-Jacob disease, and how does it spread?  How does it affect different species?  What can be done generally to protect populations against foodborne illnesses? What practices allow foodborne illnesses to spread?  (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.3.)
  4. Name at least five waterborne illnesses.  Explain how they spread. Which ones are no longer as prevalent as they once were?  How do epidemics of these diseases occasionally emerge, and what can be done to prevent such outbreaks?  What is a pandemic?  What measures can best prevent the spread of such diseases as cholera, Legionnaire’s disease, or waterborne parasites? (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.4.)
  5. Name three aerosol-dispersed diseases that have caused outbreaks in recent decades.  How are these outbreaks generally contained?  Why was it so difficult to contain the outbreak of COVID-19?  What is now being done to contain this disease?  What problems have arisen in the responses to COVID-19?  (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.4.)
  6. What is a disease vector?  Name at least five diseases spread by vectors.  What can be done to control these diseases?  Which vector-borne diseases affect the areas where you live?  Which ones are more prevalent in other parts of the world?  Why does climate change affect the prevalence of these diseases?  What can you do to best protect yourself against various vector-borne diseases? (If you cannot explain these things, or if you are not sure, then you need to reread Section 16.5.)

Open Response Study Questions

These questions are designed to assess your understanding of the topics explored in this chapter. You can use these questions in three ways:

Before you start …

Read through the questions before you read the chapter to help prime you to read the text more carefully and strategically. Remember that you are just starting out on your learning journey, so don’t feel disheartened if you don’t know how to answer them yet!

Whilst you read …

As you work through the chapter, have another go at answering the questions to see how you are progressing. You can also answer the questions with the textbook open in front of you, in order to create model answers that can be used to refer back to later.

At the end …

Answer the questions once you have finished reading to see what you have learned. Check your responses against your model answers and use these to identify any gaps in your understanding.

DEFINITIONS:

In your own words, define ANY TWO of the following terms:

prion                Chlamydia      virulence         Legionnaire’s disease              West Nile virus

Creutzfeld-Jakob disease        cholera            vector species                         primary host

ESSAYS:

Answer any two of the following questions.  Make sure to answer all parts of any question you choose.

1. Select two infectious diseases whose frequency increased in the last 50 years.  Tell what you know about (a) their

    causes & symptoms, (b) factors that promote their spread, and (c) remedies that are used to contain the spread.

2. (A) Explain the difference between a primary host, a dead-end host, and a vector species.  (B) Describe a disease

    that illustrates these concepts.

PowerPoint Slides

Download Version A (Illustrations only)
Download Version B (Topic outlines also)

Bibliography

Acuna-Soto, R., et al. 2002. Megadrought and megadeath in 16th century Mexico. Emerging Infectious Diseases 8: 360-362.

Alexander, K.A., et al. 2002. Mycobacterium tuberculosis: An emerging disease of free-ranging wildlife. Emerging Infectious Diseases 8: 598-601.

Armalagos, GJ. 1998. The viral superhighway. The Sciences Jan/Feb. 1998: 24-29.

Behbehani, A.M. 1991. The smallpox story: Historical perspective. ASM News 57: 571-576.

Beigel, J.H. et al. 2020. Remdesivir for the treatment of Covid-19– final report. New Eng. J. Med. 383: 1813-1826.

Bhimraj, A., et al.  2023.  ISDA guidelines on the treatment and management of patients with COVID-19.  Https://www.idsociety.org/COVID19guidelines

Biber, A., et al.  2021.  Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial.  MedRxiv (preprint).  Https://doi.org/10.1101/2021.05.31.21258081

Block, S.M. 2001. The growing threat of biological weapons. Amer. Scientist 89: 28-37.

Brown, P. et al. 2001. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns. Emerging Infectious Diseases 7: 6-16.

Bryant, A., et al. 2021.  Ivermectin for prevention and treatment of COVID-19 infection: a systematic review, meta-analysis, and trial sequential analysis to inform clinical guidelines. Amer. J. Therapeutics 28(4): e434-e460  https://doi.org/10.1097/MJT.0000000000001402

Caly, L. et al.   2020.   The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.  Antiviral Res. 178: 104787   https://doi.org/10.1016/j.antiviral.2020.104787

Casadevall, A., and Pirofski, L.A. 2000. Host-pathogen interactions: Basic concepts of microbial commensalism, colonization, infection, and disease. Infection and Immunity 68: 6511-6518.

Centers for Disease Control and Prevention. 2021a. History of Ebola virus disease (EVD) outbreaks. https://www.cdc.gov/vhf/ebola/history/chronology.html

Centers for Disease Control and Prevention. 2021b. Sexually transmitted infections treatment guidelines, 2021:  Mycoplasma genitalium. https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm

Centers for Disease Control and Prevention. 2021c. West Nile virus. https://www.cdc.gov/westnile/index.html

Centers for Disease Control and Prevention. 2022.  Selected adverse events reported after COVID-19 vaccination.  https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/adverse-events.html

Chen, C. et al. 2022. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review.  J. Infectious Diseases 2022  jiac136.  https://doi.org/10.1093/infdis/jiac136

Cookson, S.T., et al. 2001. Migrating populations— a closer view of who, why and so what. Emerging Infectious Diseases 7: 551.

Corum, J., and C. Zimmer. How the Novavax vaccine works. New York Times, updated May 7, 2021.  https://www.nytimes.com/interactive/2020/health/novavax-covid-19-vaccine.html?action=click&module=Top%20Stories&pgtype=Homepage

Crump, A., and S. Omura. 2011. Ivermectin, ‘wonder drug’ from Japan: the human use perspective. Proc. Japan Acad., ser. B, 87(2): 13-28. https://doi.org/10.2183/pjab.87.13

Dasak, P. et al. 1999. Emerging infectious diseases and amphibian population decline. Emerging Infectious Diseases 5: 735-748.

Davis, D.B. et al.  1973.  Microbiology.  Hagerstown, MD:  Harper and Row.

Dykewicz, C.A. 2001. Hospital infection control in hematopoietic stem cell transplant recipients. Emerging Infectious Diseases 7: 263-267.

Ewald, P.W. 1993. The evolution of virulence. Sci. American 268: 56-62.

Ewald, P.W. 1994. Evolution of infectious disease. New York: Oxford University Press.

Food and Drug Administration. 2019. FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs. Press release August 14, 2019. https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-resistant-forms-tuberculosis-affects-lungs

Food and Drug Administration. 2020. FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or

Friedman, H. 2000. From the clinical to the research laboratory: a reminiscence. ASM News 66: 137-141.

Gulbins, E., and F. Lang. 2001. Pathogens, host-cell invasion and disease. Amer. Scientist 89: 406-413.

Hindustan Times. Oct 11, 2021. Thirty-three districts in Uttar Pradesh are now Covid-free: state govt. https://www.hindustantimes.com/cities/lucknow-news/33-districts-in-uttar-pradesh-are-now-covid-free-state-govt-101631267966925.html

Huang C. et al.  2020.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.  Lancet,  DOI:https://doi.org/10.1016/S0140-6736(20)30183-5   https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

Jernigan, J.A., et al. 2001. Bioterrorism-related inhalation anthrax: The first 10 cases reported in the United States. Emerging Infectious Diseases 7: 933-944.

Kerr, L., et al. 2022a. Ivermectin prophylaxis used for COVID-19: a citywide, prospective, observational study of 223,128 subjects using Propensity Score Matching.  Cureus, 14(1): e21272.  doi:10.7759/cureus.21272  Https://www.cureus.com/articles/82162-ivermectin-prophylaxis-used-for-covid-19-a-citywide-prospective-observational-study-of-223128-subjects-using-propensity-score-matching#discussion

Kerr, L., et al. 2022b.  Regular use of ivermectin as prophylaxis for COVID-19 led up to a 92% reduction in COVID-19 mortality rate in a dose-responsive manner: results of a prospective observational study of a strictly controlled population of 88,012 subjects.  Cureus, 14(8): e28624 doi:10.7759/cureus.28624  https://www.cureus.com/articles/111851-regular-use-of-ivermectin-as-prophylaxis-for-covid-19-led-up-to-a-92-reduction-in-covid-19-mortality-rate-in-a-dose-response-manner-results-of-a-prospective-observational-study-of-a-strictly-controlled-population-of-88012-subjects#!/

Kirschner, D. 2001. Reconstructing microbial pathogenesis. ASM News 67: 566-573.

Kory, P., et al. 2021. Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19. Amer. J. Therapeutics 28(3): e299-e318, e813.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088823/

Kurokawa, C., et al. 2020. Interactions between Borrelia burgdorferi and ticks. Nature Rev. Microbiol. 18: 587-600.

Larson, E. 2001. Hygiene of the skin: When is clean too clean? Emerging Infectious Diseases 7: 225-230.

Le Vu, S., et al.  2022.  Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines.  Nature Communications 13: 3633 https://www.nature.com/articles/s41467-022-31401-5

Levy, S.B. 2001. Antibacterial household products: Cause for concern. Emerging Infectious Diseases 7: 512-515.

Lipsitch, M., and M.H. Samore. 2002. Antimicrobial use and antimicrobial resistance: A population perspective. Emerging Infectious Diseases 8: 347-354.

Manhart, L.E., J.M. Broad, and M.R. Golden. 2011. Mycoplasma genitalium, should we treat and how?  Clinical Infect. Dis. 53(suppl.3): S129-S142.

Martens, P. 1999. How will climate change affect human health? Amer. Scientist 87: 534-541.

National Institutes of Health. 2021. Coviod-19 treatment guidelines: Ivermectin. https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

Nesse, R.M., and Williams, G.C. 1998. Evolution and the origins of disease. Sci. American Nov. 1998: 86-93.

Radia, T., et al. 2021. Multi-system inflammatory syndrome in children & adolescents (MIS-C): a systematic review of clinical features and presentation. Paediatric Respiratory Reviews 38: 51-57.

RECOVERY Collaborative Group. 2021. Dexamethasone in hospitalized patients with Covid-19. New Eng. J. Med. 384: 693-704.

Rosdahl, V.T., and A.M. Knudsen. 1991. The decline of methicillin resistance among Danish Staphylococcus aureus strains. Infect. Control Hosp. Epidemiol 12(2): 83-88.

Rose, R.I. 2001. Pesticides and public health: Integrated methods of mosquito management. Emerging Infectious Diseases 7: 17-23.

Scheld, W.M., W.A. Craig and J.M. Hughes, eds. 1998. Emerging Infections. Washington, D.C.: American Society for Microbiology Press.

Seneff, S., et al.  2022.  Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quaqdruplexes, exosomes,, and MicroRNAs.  Food and Chemical Toxicology 164: 113008.  https://www.sciencedirect.com/science/article/pii/S027869152200206X  https://doi.org/10.1016/j.fct.2022.113008

Stencel, C. 2001. Research on improved foot-and-mouth disease vaccines facing challenges. ASM News 67: 290-292.

Trachtman, P. 2002. Hero for our time (Louis Pasteur). Smithsonian Jan. 2002: 34-41.

Trougakos, I.P., et al. 2022.  Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis.  Trends in Molecular Medicine.  https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00103-4   https://doi.org/10.1016/j.molmed.2022.04.007

University of Washington School of Medicine.  2022.  UW Medicine-developed COVID vaccine effective in test.  Https://newsroom.uw.edu/news/uw-medicine-developed-covid-vaccine-effective-test  Accessed 04/27/2022.

Van den Hof, S., et al. Measles outbreak in a community with very low vaccine coverage, the Netherlands. Emerging Infectious Diseases 7: 593-597.

Verma, R., P. Khanna, and S. Chawla. 2012. Cholera vaccine: new preventive tool for endemic countries. Human Vaccines Immunotherapeutics 8(5): 682-684. https://doi.org/10.4161/hv.19083

Viner R.M. and E. Whittaker.  2020.  Kawasaki-like disease:  emerging complication during the COVID-19 pandemic.  Lancet, DOI:  https://doi.org/10.1016/S0140-6736(20)31129-6   https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31129-6/fulltext

Weinstock, G.M. 2000. Genomics and bacterial pathogenesis. Emerging Infectious Diseases 6: 496- 504.

Willis, R.C. 2001. Bloodsuckers: researchers race to develop new drugs as malaria heads north. Modern Drug Discovery Oct. 2001: 40-44.

Wills, C. 2000. How we defend ourselves against infectious diseases. ASM News 66: 523-530.

World Health Organization. 2018. Zika virus.  https://www.who.int/news-room/fact-sheets/detail/zika-virus

World Health Organization. 2021a. Ebola: North Kivu, Democratic Republic of the Congo. 2021. https://www.who.int/emergencies/situations/ebola-2021-north-kivu

World Health Organization.  2021b. Uttar Pradesh going the last mile to stop COVID-19.  https://www.who.int/india/news/feature-stories/detail/uttar-pradesh-going-the-last-mile-to-stop-covid-19

Worldometer. 2021. Coronavirus. https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html